Dihydrocodeine and Ibuprofen — Safe Combo?
For most adults, yes — dihydrocodeine and ibuprofen can safely be taken together, and the combination is more effective than either drug alone.
How the combination works
Ibuprofen is an NSAID — it reduces inflammation at the site of injury. Dihydrocodeine is an opioid — it blocks pain signal transmission to the brain. Together they hit the pain from both ends.
Safe adult dosing
- Ibuprofen: 400mg every 6–8 hours, maximum 1.2g (1,200mg) in 24 hours for over-the-counter use
- Dihydrocodeine 30mg: one tablet every 4–6 hours, maximum 180mg in 24 hours
Take ibuprofen with food to protect your stomach.
When to avoid ibuprofen
- History of stomach ulcers or GI bleeding
- Kidney disease
- Heart failure or uncontrolled high blood pressure
- Asthma triggered by NSAIDs
- Pregnancy (especially third trimester)
- Already on blood thinners (warfarin, apixaban) without medical advice
If any of these apply, paracetamol is a safer partner for dihydrocodeine. See paracetamol with dihydrocodeine.
Can you take all three together?
Yes — paracetamol + ibuprofen + dihydrocodeine is the classic UK “triple stack” for severe acute pain after surgery or fractures. Stick to the maximum daily doses of each.
Order dihydrocodeine
Order dihydrocodeine online from Dihydrocodeine UK Store.